EPCS - Electronic Prescribing of Controlled Substances

Save time and money by using MDToolbox’s Certified EPCS solution

EPCS e-Prescribing of Controlled Substances

MDToolbox-Rx is fully certified to Send Controlled Substance Prescriptions Electronically. As e-Prescribing becomes the norm, the need for electronically prescribing Schedule II-V drugs is becoming greater.

The Federal DEA (Drug Enforcement Agency) requires that EPCS software meet strict requirements and go through a third-party audit to check that these requirements are met. The MDToolbox e-Prescribing system has both been audited by a Qualified DEA Auditor and Certified by Surescripts® to Electronically Send Controlled Substances. We were the 4th eRx program in the U.S. to achieve this EPCS certification.

With MDToolbox EPCS, you can:

  • e-Prescribe Schedule II-V drugs

  • Utilize one easy to use workflow for all prescribing

  • Improve security and patient safety

  • Integrate your State PMP (in most States)

EPCS e-Prescribing of Controlled Substances

How Does EPCS Work?

The DEA requires a 2-Factor Authentication sign off, meaning when a prescriber electronically sends a controlled substance prescription they must sign it using something they know (e.g. a password) and something they have (e.g. a token). Each prescriber who wishes to e-Prescribe controlled substances must go through an identity proofing and authentication process in order to receive a token. This ensures the system is secure and safe!

Where is EPCS allowed?

E-Prescribing of Controlled Substances is allowed in all 50 states. Check the table below to see the number of pharmacies enabled for e-Prescribing and EPCS in your state.

  • EPCS Allowed (Schedule II-V)
  • # of e-Prescribing Pharmacies*
  • 1401
  • 129
  • 1380
  • 758
  • 6691
  • 1092
  • 731
  • 214
  • 145
  • 5879
  • 2574
  • 244
  • 392
  • 2358
  • 1457
  • 747
  • 669
  • 1210
  • 1242
  • 304
  • 1302
  • 1164
  • 2533
  • 1052
  • 764
  • 1358
  • 273
  • 471
  • 592
  • 282
  • 2220
  • 387
  • 5255
  • 2241
  • 197
  • 2462
  • 961
  • 676
  • 3044
  • 179
  • 1233
  • 214
  • 1742
  • 5559
  • 556
  • 144
  • 1639
  • 1349
  • 558
  • 1182
  • 133
  • % of EPCS Enabled Pharmacies
  • 98%
  • 94%
  • 97%
  • 99%
  • 96%
  • 93%
  • 99%
  • 98%
  • 97%
  • 94%
  • 97%
  • 95%
  • 97%
  • 96%
  • 97%
  • 99%
  • 98%
  • 98%
  • 97%
  • 99%
  • 96%
  • 99%
  • 98%
  • 97%
  • 96%
  • 96%
  • 94%
  • 96%
  • 97%
  • 96%
  • 97%
  • 89%
  • 99%
  • 97%
  • 98%
  • 98%
  • 97%
  • 98%
  • 98%
  • 98%
  • 96%
  • 93%
  • 95%
  • 98%
  • 98%
  • 98%
  • 96%
  • 97%
  • 97%
  • 96%
  • 99%


*Number of pharmacies is approximate and current as of May 2023.