EPCS - Electronic Prescribing of Controlled Substances

Save time and money by using MDToolbox’s Certified EPCS solution

EPCS e-Prescribing of Controlled Substances

MDToolbox-Rx is fully certified to Send Controlled Substance Prescriptions Electronically. As e-Prescribing becomes the norm, the need for electronically prescribing Schedule II-V drugs is becoming greater.

The Federal DEA (Drug Enforcement Agency) requires that EPCS software meet strict requirements and go through a third-party audit to check that these requirements are met. The MDToolbox e-Prescribing system has both been audited by a Qualified DEA Auditor and Certified by Surescripts® to Electronically Send Controlled Substances. We were the 4th eRx program in the U.S. to achieve this EPCS certification.

With MDToolbox EPCS, you can:

  • e-Prescribe Schedule II-V drugs

  • Utilize one easy to use workflow for all prescribing

  • Improve security and patient safety

  • Integrate your State PMP (in most States)

EPCS e-Prescribing of Controlled Substances

How Does EPCS Work?

The DEA requires a 2-Factor Authentication sign off, meaning when a prescriber electronically sends a controlled substance prescription they must sign it using something they know (e.g. a password) and something they have (e.g. a token). Each prescriber who wishes to e-Prescribe controlled substances must go through an identity proofing and authentication process in order to receive a token. This ensures the system is secure and safe!

Where is EPCS allowed?

E-Prescribing of Controlled Substances is allowed in all 50 states. Check the table below to see the number of pharmacies enabled for e-Prescribing and EPCS in your state.

  • EPCS Allowed (Schedule II-V)
  • # of e-Prescribing Pharmacies*
  • 1424
  • 126
  • 1380
  • 769
  • 6691
  • 1082
  • 729
  • 216
  • 152
  • 5834
  • 2529
  • 246
  • 381
  • 2384
  • 1459
  • 734
  • 674
  • 1205
  • 1251
  • 310
  • 1302
  • 1165
  • 2544
  • 1053
  • 765
  • 1377
  • 272
  • 478
  • 585
  • 285
  • 2206
  • 392
  • 5246
  • 2242
  • 199
  • 2494
  • 958
  • 680
  • 3061
  • 185
  • 1223
  • 212
  • 1735
  • 5611
  • 550
  • 146
  • 1658
  • 1351
  • 557
  • 1163
  • 135
  • % of EPCS Enabled Pharmacies
  • 97%
  • 93%
  • 96%
  • 98%
  • 96%
  • 93%
  • 98%
  • 96%
  • 94%
  • 94%
  • 97%
  • 95%
  • 97%
  • 95%
  • 97%
  • 99%
  • 98%
  • 98%
  • 97%
  • 99%
  • 95%
  • 99%
  • 98%
  • 96%
  • 96%
  • 96%
  • 94%
  • 96%
  • 96%
  • 96%
  • 97%
  • 90%
  • 99%
  • 96%
  • 98%
  • 98%
  • 97%
  • 98%
  • 98%
  • 97%
  • 96%
  • 93%
  • 95%
  • 97%
  • 98%
  • 98%
  • 95%
  • 97%
  • 96%
  • 96%
  • 97%


*Number of pharmacies is approximate and current as of June 2022.