EPCS - Electronic Prescribing of Controlled Substances

Save time and money by using MDToolbox’s Certified EPCS solution

EPCS e-Prescribing of Controlled Substances

MDToolbox-Rx is fully certified to Send Controlled Substance Prescriptions Electronically. As e-Prescribing becomes the norm, the need for electronically prescribing Schedule II-V drugs is becoming greater.

The Federal DEA (Drug Enforcement Agency) requires that EPCS software meet strict requirements and go through a third-party audit to check that these requirements are met. The MDToolbox e-Prescribing system has both been audited by a Qualified DEA Auditor and Certified by Surescripts® to Electronically Send Controlled Substances. We were the 4th eRx program in the U.S. to achieve this EPCS certification.

With MDToolbox EPCS, you can:

  • e-Prescribe Schedule II-V drugs

  • Utilize one easy to use workflow for all prescribing

  • Improve security and patient safety

EPCS e-Prescribing of Controlled Substances

How Does EPCS Work?

The DEA requires a 2-Factor Authentication sign off, meaning when a prescriber electronically sends a controlled substance prescription they must sign it using something they know (e.g. a password) and something they have (e.g. a token). Each prescriber who wishes to e-Prescribe controlled substances must go through an identity proofing and authentication process in order to receive a token. This ensures the system is secure and safe!

Where is EPCS allowed?

E-Prescribing of Controlled Substances is allowed in all 50 states. Check the table below to see the number of pharmacies enabled for e-Prescribing and EPCS in your state.

  • EPCS Allowed (Schedule II-V)
  • # of e-Prescribing Pharmacies*
  • 1,410
  • 125
  • 1,344
  • 762
  • 6,742
  • 1,027
  • 725
  • 219
  • 159
  • 5,609
  • 2,418
  • 255
  • 365
  • 2,348
  • 1,460
  • 734
  • 678
  • 1,193
  • 1,247
  • 306
  • 1,310
  • 1,184
  • 2,542
  • 1,040
  • 765
  • 1,356
  • 268
  • 481
  • 558
  • 284
  • 2,220
  • 385
  • 5,190
  • 2,207
  • 203
  • 2,431
  • 964
  • 715
  • 3,118
  • 194
  • 1,196
  • 209
  • 1,665
  • 5,548
  • 564
  • 144
  • 1,645
  • 1,360
  • 563
  • 1,159
  • 132
  • % of EPCS Enabled Pharmacies
  • 96%
  • 86%
  • 95%
  • 97%
  • 94%
  • 92%
  • 98%
  • 95%
  • 94%
  • 93%
  • 95%
  • 91%
  • 96%
  • 95%
  • 96%
  • 98%
  • 96%
  • 97%
  • 95%
  • 99%
  • 94%
  • 98%
  • 97%
  • 95%
  • 94%
  • 95%
  • 91%
  • 93%
  • 95%
  • 95%
  • 96%
  • 87%
  • 99%
  • 95%
  • 95%
  • 97%
  • 96%
  • 95%
  • 97%
  • 96%
  • 96%
  • 90%
  • 94%
  • 96%
  • 97%
  • 97%
  • 95%
  • 96%
  • 95%
  • 95%
  • 93%


*Number of pharmacies is approximate and current as of January 2021.