EPCS - Electronic Prescribing of Controlled Substances

Save time and money by using MDToolbox’s Certified EPCS solution

EPCS e-Prescribing of Controlled Substances

MDToolbox-Rx is fully certified to Send Controlled Substance Prescriptions Electronically. As e-Prescribing becomes the norm, the need for electronically prescribing Schedule II-V drugs is becoming greater.

The Federal DEA (Drug Enforcement Agency) requires that EPCS software meet strict requirements and go through a third-party audit to check that these requirements are met. The MDToolbox e-Prescribing system has both been audited by a Qualified DEA Auditor and Certified by Surescripts® to Electronically Send Controlled Substances. We were the 4th eRx program in the U.S. to achieve this EPCS certification.

With MDToolbox EPCS, you can:

  • e-Prescribe Schedule II-V drugs

  • Utilize one easy to use workflow for all prescribing

  • Improve security and patient safety

EPCS e-Prescribing of Controlled Substances

How Does EPCS Work?

The DEA requires a 2-Factor Authentication sign off, meaning when a prescriber electronically sends a controlled substance prescription they must sign it using something they know (e.g. a password) and something they have (e.g. a token). Each prescriber who wishes to e-Prescribe controlled substances must go through an identity proofing and authentication process in order to receive a token. This ensures the system is secure and safe!

Where is EPCS allowed?

E-Prescribing of Controlled Substances is allowed in all 50 states. Check the table below to see the number of pharmacies enabled for e-Prescribing and EPCS in your state.

  • EPCS Allowed (Schedule II-V)
  • # of e-Prescribing Pharmacies*
  • 1,433
  • 128
  • 1,329
  • 765
  • 6,747
  • 1,029
  • 746
  • 218
  • 160
  • 5,623
  • 2,413
  • 265
  • 358
  • 2,375
  • 1,495
  • 732
  • 673
  • 1,176
  • 1,239
  • 309
  • 1,312
  • 1,179
  • 2,528
  • 1,061
  • 764
  • 1,397
  • 271
  • 481
  • 557
  • 290
  • 2,197
  • 378
  • 5,185
  • 2,230
  • 202
  • 2,434
  • 975
  • 718
  • 3,185
  • 194
  • 1,226
  • 210
  • 1,660
  • 5,507
  • 570
  • 151
  • 1,654
  • 1,387
  • 573
  • 1,161
  • 130
  • % of EPCS Enabled Pharmacies
  • 95%
  • 85%
  • 95%
  • 96%
  • 92%
  • 92%
  • 97%
  • 96%
  • 94%
  • 91%
  • 94%
  • 89%
  • 95%
  • 94%
  • 96%
  • 98%
  • 95%
  • 97%
  • 94%
  • 99%
  • 93%
  • 98%
  • 97%
  • 94%
  • 92%
  • 95%
  • 90%
  • 92%
  • 94%
  • 96%
  • 96%
  • 87%
  • 98%
  • 95%
  • 95%
  • 96%
  • 96%
  • 95%
  • 97%
  • 95%
  • 95%
  • 90%
  • 93%
  • 95%
  • 96%
  • 97%
  • 94%
  • 93%
  • 95%
  • 96%
  • 90%


*Number of pharmacies is approximate and current as of February 2020.